This interactive presentation outlines a global WHO-commissioned project that reviews research methods used in the field of traditional medicine (TM), with a strong emphasis on epistemological sensitivity. The initiative explores how research methodologies, strategies, and frameworks can be aligned with the diverse worldviews and paradigms inherent in traditional, Indigenous, and complementary health systems. Central to the project are the concepts of epistemic pluralism and "Two-Eyed Seeing"—a Mi’kmaw approach promoting the coexistence of Indigenous and biomedical knowledge systems. The review aims to identify barriers and enablers to implementing paradigm-appropriate TM research and evidence synthesis, through a two-stage process: a scoping review and a mixed-methods systematic review. Consultations with global stakeholders and experts will inform the development of culturally and conceptually aligned methodologies. The project also seeks to inform global policy by proposing context-specific approaches that validate the integrity of TM while engaging with modern evidence standards.